【CAS No.】 9009-65-8
【Formula 】NA

【National Medicine Permission Number】 H11020228

【Drug Class】 anti-heparin drugs

【Formulation Use】Protamine sulfate injection（1）5ml：50mg （2）10ml：100mg

【Packing Specification】1kg/barrel、5kg/Barrel

【Standard】 CP, EP,USP,BP ,ect 

【Description】:

Protamine sulfate is indicated for counteracting or reversing the anticoagulant effect of heparinas necessary. Such reversal may, for example, be required often before surgery; after renalhemodialysis; post open heart surgery; whenever excessive bleeding results from heparin use;and/or for the treatment of heparin overdosage, among other similar or related circumstances.

Protamine sulfate is a medication primarily used to reverse the anticoagulant effects of heparin, a common blood thinner. Here’s how it works:

Mechanism of Action

Chemical Structure: Protamine sulfate is a small, positively charged (cationic) protein derived from the sperm of salmon or other fish. It is composed of a high proportion of arginine residues, giving it a strong positive charge.

Clinical Use
Reversal of Heparin Anticoagulation: Protamine sulfate is used during or after surgeries and medical procedures where heparin has been administered to prevent blood clotting. It is especially useful in cardiac surgeries, vascular surgeries, and dialysis